I really should make a blog post or something about this as I've helped a few people out. But basic rules of thumb for me cutting aluminum 6061-T6 on a CNC router using a 2.2kw spindle, and not having like, the most heavy duty of machines, is roughly as follows:
1/8 single flue carbide (name brand endmills only) dry cut, materials up to .032 cut at full depth thru with a little extra, usually spec a .040-.050 DOC to account for any variations in spoilboard level. Anything over .032 thick, take .025 or less DOC passes, with one pass "above" and one pass "below" the material, again to account for variations in spoilboard level. (If your machine has a fresh surface or a more stable spoilboard than, say, MDF, you can dial that in better.) Moving in the 30ipm range.
If I'm cutting thicker materials (.125+) I will often be standing by with a can of WD-40 and once there's a pass or two around the perimiter I'll give the occasional shot into the channel to help clear chips and add some lubricity. If cutting very thick parts with a small perimiter, heat buildup can be an issue so more WD, or cut halfway down, let it cool for a bit, then resume the cut. Anything to prevent chipweld.
I've cut a little bit of 2024 as well. It is harder, so maybe do about 80% of the above as a starting point.
A heavier duty machine can probably do about 150% the above numbers as a starting point, but mostly in that it can accurately push through a heavier cut. It needs to be able to throw good chip to move at the higher speeds otherwise the heat buildup is still the #1 issue I've run into.