I can't see that operating a VW engine at a lower cruise rpm with a larger prop is likely to do any harm to the engine though obviously the prop clearance could become an issue of the change is significant.
Off the top of my head, the VP-2 specifies a 60 x 30" prop for an 1835cc engine and a 60 x 32" for a 2180cc. If those are running at a 3600 RPM redline, you're looking at a propeller tip speed of 643 mph or .84 mach. Looking at the Aerovee numbers, you only need to go down to 2700 RPM to hit 65 hp and that allows you to run a prop up to 80" in diameter for the same tip speed. That's a huge change, 10" increase in prop clearance required which would require completely new gear on the VP-2. I suppose you could go with a 3-bladed propeller at the original diameter or close to it, but then you're operating the propeller at far less than the optimum .8-.92 mach range for best efficiency.
I guess it comes down to the aircraft. If it already has the clearance for a large prop, or it's a replica or some sort that will look better with a large prop, then the 2180cc with a big, slow prop makes sense. If it's something without the ground clearance, then you're probably better off with the stock 1835cc and prop size.