I've flown Pratt DC-3s a bit, right seat, eons ago. Never did this. Select auto-rich or auto-lean as the case may be.It is standard practice on the Pratts to enrichen and re-lean every hour or 1,000 foot of altitude change. It is good to start at a baseline periodically with them.
In any case, we don't do this on modern EFI equipped engines either. Once cruise power is set, we select LOP mode usually via the switch or keypad. This leans the programmed amount (usually 20-25%) and simultaneously advances timing 3-5 degrees to help restore some of the lost power due to the slower burning lean mixture. Climb mixture is automatically controlled by MAP and baro.
I thought this thread was about simple EFI to replace carbs on small 2 and 4 stroke engines. What will be gained with more layers of complexity on these small engines which don't burn much fuel to begin with? 2 strokes certainly don't take kindly to be running lean at all.
We are currently working with a company in the US to develop an SDS kit for the Honda 650 single cylinder engine for aviation.